Abstract: Alzheimer’s disease（AD）, commonly known as senile dementia disease, is a neurodegenerative disease with a slow onset process and deteriorating over time. This study described the course of Alzheimer’s disease by stages according to the deterioration of cognitive ability and physical function, and the symptoms, clinical diagnosis and nursing of prophase, early, middle and late stages were analyzed systematically. The aim is to fully understand the symptoms and signs of Alzheimer’s disease as well as to provide a theoretical basis for the prevention and early intervention of Alzheimer’s disease.