Abstract: Flos chrysanthemi indici is a traditional Chinese medicinal material, and its extract can effectively inhibit a variety of tumor cells. Nasopharyngeal carcinoma（NPC） is a head and neck malignant tumor with high incidence in China, but it is not clear whether Flos chrysanthemi indici has curative effect on. To explore the target and mechanism of wild chrysanthemum in the treatment of nasopharyngeal carcinoma by network pharmacology, the active components and action targets of Flos chrysanthemi indici were searched by TCMSP database based on oral bioavailability（OB≥30%） and drug-like drugs（DL≥0.18）. The NPC-related disease targets were searched by GeneCards database. The Flos chrysanthemi indici active component-nasopharyngeal carcinoma disease target network map was constructed by Cytoscape 3.6.1 software, and GO functional annotations and KEGG pathway enrichment analysis were carried out by using DAVID database. The results showed that six active components and51 potential targets of Flos chrysanthemi indici in the treatment of nasopharyngeal carcinoma were obtained. The active component-key target-pathway network map showed that the key targets included TP53, JUN, CASP3,CASP9, EGFR, PTGS2, BCL2 L1, CASP8 and other targets. 30 molecular functional items, 122 biological process items and 18 cell composition items were obtained by GO functional annotations, and 20 related pathways were obtained by KEGG pathway enrichment, involving PI3 K-Akt signal pathway, cancer signal pathway, apoptosis pathway and EB virus infection pathway and other signal pathways. The above results indicate Flos chrysanthemi indici in the treatment of nasopharyngeal carcinoma is mainly through TP53, JUN, EGFR, PTGS2 and other targets and related signal pathways, and then play a role in the treatment of nasopharyngeal carcinoma.