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超声参数、血清ALD、Renin水平与高血压患者肾功能关联性分析

Correlation Analysis of Ultrasound Parameters,Serum ALD and Renin Levels and Renal Function in Patients with Hypertension

  • 摘要: 为分析超声参数、血清醛固酮(serum aldosterone, ALD)、肾素(Renin)水平与高血压患者肾功能的关联性及临床表达意义,选取2020年3月~2021年1月安徽医科大学附属阜阳医院高血压患者99例,将其中伴有早期肾损害的43例设为肾损害组,其余56例设为无肾损害组。入院后抽取两组血液样本测定血清ALD、Renin水平,并进行超声检查。统计两组超声参数叶间动脉搏动指数(pulsatility index, PI),阻力指数(resistance index, RI)、血清ALD、Renin、肾功能指标尿中性粒细胞明胶酶相关载脂蛋白(neutrophil gelatinase-associated apolipoprotein, NGAL),肾损伤分子-1 (kidney injury molecule-1, KIM-1)水平。以尿NGAL、KIM-1测定结果除以尿肌酐(creatinine, Cr)为最终测定结果,分析超声参数、血清ALD、Renin水平与肾功能指标、早期肾损害间关联性及对高血压早期肾损害预测价值。肾损害组血清ALD、Renin水平、PI、RI值、尿KIM-1/Cr、NGAL/Cr水平均高于无肾损害组(P<0.05);Pearson相关性分析显示,高血压患者血清ALD、Renin水平、PI、RI值与尿KIM-1/Cr、NGAL/Cr水平呈正相关关系(P<0.05);Logistic回归分析显示,血清ALD、Renin与PI、RI均为高血压患者发生早期肾损害的重要危险因素(P<0.05);血清ALD、Renin水平与PI、RI值联合预测高血压患者早期肾损害的敏感度为81.40%,异度为87.50%。超声参数、血清ALD、Renin水平与高血压患者肾功能具有明显相关性,可用于预测高血压早期肾损害。

     

    Abstract: To analyze the correlation and clinical expression significance of ultrasound parameters, serum aldosterone(ALD) and Renin levels with renal function in patients with hypertension, a total of 99 patients with hypertension in Fuyang hospital affiliated to Anhui medical university from March 2020 to January 2021 were selected,and 43 of them with early renal damage were selected as the group of renal damage, and the remaining 56 cases were set as the group without kidney damage. After admission, two blood samples were taken to determine serum ALD and Renin levels, and an ultrasound examination was performed. Counting the ultrasound parameters interlobular artery pulsatility index(PI), resistance index(RI), serum ALD, Renin, and renal function indexes urine neutrophil gelatinase-associated apolipoprotein(NGAL), kidney injury molecule-1(KIM-1) of the two groups. Urine NGAL, KIM-1 measurement results divided by urine creatinine(Cr) as the final measurement results, the corre lation between ultrasound parameters, serum ALD, Renin levels and renal function indexes, early renal damage and the predictive value of early renal damage in hypertension were analyzed. The levels of serum ALD, Renin, PI, RI,urinary KIM-1/Cr, NGAL/Cr in the renal damage group were higher than those in the non-renal damage group(P<0.05). Pearson correlation analysis showed that serum ALD, Renin level, PI, RI values of patients with hypertension were positively correlated with urine KIM-1/Cr and NGAL/Cr levels(P <0.05). Logistic regression analysis showed that serum ALD, Renin, PI, and RI were important risk factors for early renal damage in patients with hypertension(P<0.05). The sensitivity of serum ALD, Renin, PI and RI to predict early renal damage in hypertensive patients was 81.40%, and the specificity was 87.50%. Ultrasound parameters, serum ALD and Renin levels have a significant correlation with renal function in patients with hypertension, and can be used to predict early renal damage in patients with hypertension.

     

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