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IMPDH2细胞蛇的组装及影响因素

Assembly and Influencing Factors of IMPDH2 Cytoophidia

  • 摘要: 细胞蛇是一种由代谢相关的酶组成的“杆”或“环”状结构。肌苷-5'-单磷酸脱氢酶(inosine-5'-monophosphate dehydrogenase, IMPDH)是催化鸟嘌呤核苷酸的从头生物合成途径中的限速酶,在细胞增殖、细胞分化、维持机体平衡以及新陈代谢中扮演着非常重要的角色。研究发现,IMPDH2蛋白可以组装成一种特殊结构的蛋白质聚合物纤维,命名为IMPDH2细胞蛇,该结构是与嘌呤代谢相关的天然生物学现象,作为微调蛋白适应细胞内和细胞外的环境变化。本综述对IMPDH2及IMPDH2细胞蛇的结构、IMPDH2细胞蛇的组装过程及影响因素进行综述。

     

    Abstract: Cytoophidium is a "rod" or "ring" structure composed of metabolically related enzymes. Inosine-5’-monophosphate dehydrogenase(IMPDH) is a rate-limiting enzyme that catalyzes the de novo biosynthetic pathway of guanine nucleotides and plays a very important role in cell proliferation, cell differentiation, maintenance of body balance and metabolism. The study found that IMPDH2 protein can be assembled into a special structure of protein polymer fibers, named IMPDH2 cytoophidia, the structure was a natural biological phenomenon related to purine metabolism, as a fine-tuning protein adapted to the intracellular and extracellular environment changes. This article reviews the structure of IMPDH2 and IMPDH2 cytoophidia, the assembly process and the influencing factors of IMPDH2 cytoophidia.

     

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