Abstract: The study explored the effects of 12-week FATmax intensity exercise on blood glucose, blood lipids and liver function on obese non-alcoholic fatty liver disease（NAFLD） patients, and provided exercise prescription reference for rehabilitation of NAFLD patients. 54 obese college students with NAFLD were randomly divided into exercise group and control group. The exercise group received FATmax intensity exercise intervention 4 times a week for 12 weeks, and the control group did not take any form of systematic sports. The four items of blood glucose, insulin resistance index, 4 items of blood lipids and 14 items of liver function were tested before and after the test. The results are as follows:（1） After the test, body weight（P=0.017, ES=0.856）, body fat percentage（P=0.043, ES=0.776）, muscle content（P=0.030, ES=0.781）, and BMI（P=0.005, ES=1.039） showed interaction between groups and time. The weight（P＜0.05）, body fat percentage（P＜0.05） and BMI（P＜0.01） of the exercise group were significantly lower than that of those of the control group, and the muscle content was significantly higher than the control group（P＜0.05）.（2） After the test, TC（P=0.021, ES=0.929）, HDL-C（P=0.032, ES=0.747）, ALT（P=0.028, ES=0.869）, AST（P=0.048, ES=0.761）, TBIL-V（P=0.038, ES=0.810）, GGT（P=0.049, ES=0.757） showed inter-group and time interaction, and compared with control group, TC, ALT, AST, TBIL-V, GGT in the exercise group were significantly lower（P＜0.05）, HDL-C was significantly higher（P＜0.05）. The study indicated that 12 weeks of FATmax intensity exercise can significantly reduce body fat in obese NAFLD patients, improve blood lipid metabolism, reduce liver damage, and increase muscle mass in patients.