Abstract: CecropinXJ（CEC） can exhibit good inhibitory effect on cervical cancer cells, but it is difficult to precisely controlthe drug to arrive the tumor site. Nanomedicine delivery systems hold tremendous potential as an effective drug delivery system. In this study, a novel folate functionalized FA-ZIF-8@CEC nanoparticle based on a metal-organic framework was developed to transport CEC for cervical cancer. The characterization results of infrared spectroscopy, ultraviolet-visible absorption spectroscopy, nuclear magnetic hydrogen spectroscopy, X-ray diffraction（XRD）, scanning electron microscopy（SEM）, transmission electron microscopy（TEM）, and other methods showed that FA-ZIF-8@CEC nanoparticles were successfully prepared. MTT results showed that the FA-ZIF-8@CEC exhibited higher anticancer efficiency in HeLa cells compared to free CEC and ZIF-8@CEC, indicating promising potential for targeted treatment of cervical cancer. The results show that folate-functionalized FA-ZIF-8@CEC nanoparticles have broad application prospects in targeted drug delivery for cervical cancer.