Abstract: Coronary heart disease（CHD） is a complex disease with the highest mortality and disability rates worldwide. It is primarily caused by a combination of genetic and environmental factors, resulting in a diverse range of phenotypes. The genetic component signifi-cantly influences the development of coronary heart disease, and the pathological molecular mechanism is complex. It is crucial to understand the susceptibility genes linked to it in order to grasp its pathogenesis. This article offers an overview of the connection between different susceptibility genes, including androgen-dependent TFPI regulating protein（ADTRP）, apolipoprotein（Apo） gene family, fat factor, inflammatory cytokine, and the progression of coronary heart disease.