Abstract: The adsorption kinetics and thermodynamics of the rosin-based macroporous adsorption resin which was used as an adsorbent for ligustrazine hydrochloride was studied through static adsorption experiments. The results showed that the adsorption rates of ligustrazine hydrochloride onto rosin-based macroporous adsorption resin gradually reduced with time, and followed the second-order kinetics, and basically reached equilibrium after 3.5 hours. The adsorption process belongs to slow adsorption, and it is effected by film diffusion and intra-particle diffusion. The equilibrium for the adsorption of ligustrazine hydrochloride from aqueous solutions by rosin-based macroporous adsorption resin could be fitted to Langmuir-type of isotherm equation and maximum sorption was about 144.5 mg/g when the optimum temperature was 313 K. The studies on the thermodynamics showed that the adsorption ΔH>0, ΔS>0, the change in free energy of adsorption decreases from positive to negative with the increment of temperature, the adsorption process is a spontaneous and endothermic one.