复方肝康化学成分研究

Chemical Components of Chinese Herbal Formula of Gankang

摘要: 以75%乙醇提取中药复方制备总浸膏,硅胶柱色谱等分离其化学成分,波谱法鉴定其结构。分离得到13个已知化合物,分别为顺式白藜芦醇3-O-β-葡萄糖苷(1)、山萘酚3-O-β-D-吡喃葡萄糖苷(2)、山萘酚(3)、4'-二氢红花菜豆酸(4)、leptosphaepin(5)、熊果苷(6)、4-咖啡酰基奎宁酸(7)、3,4-二甲氧基苯乙醚(8)、2-叔丁基-4-羟基茴香醚(9)、α-生育醌(10)、异香草酸(11)、甘露醇(12)、β-胡萝卜苷(13)。这些化合物均为首次从该中药复方中分离得到。

Abstract: To study the hypoglycemic mechanism from Chinese Herbal Formula of Gankang, the chemical constituents of its active fraction were investigated in this study. Thirteen compounds were isolated and purified by silica gel column, Sephadex LH-20, and C18 chromatography, respectively. Their chemical structures were elucidated on the basis of physicochemical properties and spectral data. Thirteen compounds were identified as: (Z)-resveratrol(3,5,4'-trihydroxystilbene)-3-O-β-glucoside(1), kaemperol-3-O-β-D-glucopyranoside(2), kaemperol(3), 4'-dihydrophaseic acid(4), leptosphaepin(5), arbutin(6), 4-caffeoyl quinic acid(7), 3,4-dimethoxyphenyl-ethyl-ether(8), 2-butylated-4-hydroxyanisole(9), α-tocoquinone(10), isovanillic acid(11), mannitol(12) and β-daucosterol(13). They are all firstly isolated from this traditional Chinese medicine