Abstract: Magnetic molecularly imprinted polymer(MIP)was prepared by using magnetic iron oxide as the carrier, curcumin as the template molecule, methacrylic acid as the functional monomer and ethylene glycol dimethacrylate as the cross-linker. The Fe3O4@SiO2@MIP was characterized by scanning electron microscope, thermogravimetric analysis, vibrating sample magnetometer and infrared spectroscopy. The results showed that the Fe3O4@SiO2@MIP was prepared on magnetic iron oxide surface successfully. The adsorption properties were investigated by high performance liquid chromatography. The results demonstrated that the Fe3O4@SiO2@MIP exhibited specific selectivity toward curcumin. The maximum adsorption capacity on Fe3O4@SiO2@MIP was 36.2 mg/g, and the selectivity factors of curcumin toward rhein and emodin were 2.0 and 2.2, respectively. Combined with magnetic solid phase extraction and high-performance liquid chromatography technology, the Fe3O4@SiO2@MIP was used to separate, enrich and detect curcumin in ginger powder, sample solution successfully with the recoveries of 99.2%-107%.