Abstract: Synthesis of natural anisyl acetone was investigated by using natural base to Asia anisyl acetone as raw material, Lewis acid as catalyst, cyclohexane as a source of hydrogen. Different Lewis acid catalysts with different solvents were screened. The optimum synthesis conditions were determined based on the orthogonal test results as follows: the reaction temperature is 35℃, n(AlCl3):n(asia anisyl acetone)4:1 and n(cyclohexane):n(asia anisyl acetone)4:1.Three experiments were carried out under these conditions. A good stability was obtained. The yield of the product 4-(4-methoxyphenyl)-2-butanone could reach 95%. Reaction mechanism and selective of product were discussed. The structure of the product was identified by FT-IR, GC-MS and 1H NMR spectrum.