Abstract: Diclofenac sodium, ciprofloxacin and theophylline were used as model drugs to study the drug release properties and kinetics of rosin-based polyacrylamide hydrogels. The results indicated that the equilibrium swelling ratios of hydrogels decreased with the increase of the amount of rosin-based cross-linking agent FPA-PEG200-AC. And the equilibrium swelling ratio was largest(12 g/g) in the pH 7.4 PBS buffer solution, followed by the deionized water and it was the smallest in the pH 1.4 hydrochloric acid solution. The drug release properties of hydrogels prepared with different amounts of cross-linking agent showed that the diclofenac sodium was mainly released within 1 h, and reached the maximum values of cumulative release within 3 h. The ciprofloxacin was released slowly and reached the maximum values of cumulative release within 8 h; when the amount of FPA-PEG200-AC was 0.025 g/mL in hydrogel, the maximum values of cumulative release was about 99.7%. The maximum values of theophylline release in pH 7.4 PBS buffer could reach 99%, which was higher than the cumulative release rate in pH 1.4 hydrochloric acid solution. The drug release data of hydrogels were fitted into Higuchi models (r2=0.873-0.999) and Korsmeyer-Peppas models (r2=0.887-0.999, the diffusional exponent n< 0.5, Fick diffusion); the drug release of hydrogels was best explained by Higuchi models when the dosage of FPA-PEG200-AC was 0.020 and 0.030 g/mL.