Abstract: In order to evaluate the adsorption and purification capability of ZSM-5 molecular sieve on the lycorine and galanthamine, the adsorption and desorption performance of the three adsorbents (including ZSM-5 molecular sieve, cation exchange resin, macroporous resin) on the lycorine and galanthamine from Lycoris aurea were investigated, and then the adsorption kinetics were also studied. The results showed that ZSM-5 had obvious advantages in adsorption and elution of lycorine and galanthamine compared with macroporous resin (AB-8 and D-101) and cation adsorption resin (D-001 and HD-8). Adsorption rates of lycorine and galanthamine on ZSM-5 achieved more than 99.5% and the elution rates achieved 90.35% and 84.84%, respectively. The adsorption rates of D-101 and AB-8 were high, but the elution rates were only about 75%. Adsorption rates of lycorine on D-101 and AB-8 were high, but those of galanthamine were only 14.50% and 20.56%. The result of kinetics study indicated that the adsorption of lycorine and galanthamine on ZSM-5 was in good consistent with the second order kinetics model (R2=0.999 9), and chemisorption occupied the leading role.