Abstract: A novel six armed cardanol-derived epoxy resin containing a cyclotri phosphazene core(EHCPP) was successfully synthesized by two steps. Firstly, cardanol reacted with hexachlorocyclotriphosphazene(HCCP) to produce hexasubstituted cardanol with cyclotriphosphazene core(HCPP) with NaH as acid binding agent; secondly, EHCPP was generated by epoxidation of HCPP with the H₂O₂/HCOOH system, the synthesis conditions of EHCPP were optimized by orthogonal experiment, and the intermediate product HCPP and the final product EHCPP were analyzed and characterized by FT-IR and ¹H NMR. The results showed that the optimum synthesis conditions of EHCPP were as follows n(double bond of cardanol):n(formic acid)=1.0:1.0, n(double bond of cadanol):n(H₂O₂)=1.0:1.8, catalyst TsOH 1% relative to the mass of HCPP, the reaction temperature 65℃, the reaction time 6 h, and the results of FT-IR and ¹H NMR analysis showed that the structures of HCPP and EHCPP were basically consistent with the expected structures and its epoxy value was 4.1 mmol/g.