Abstract: The epoxy-activated cellulose fibers(CPGMA) were subjected to polyamination organic synthesis in water medium and in dimethylamide(DMF) medium, respectively. The effects of reaction medium, amine concentration, reaction time, temperature, liquid ratio and initial epoxy group content on the amination reaction were investigated. The results showed that DMF as the reaction medium and the temperature of 60 ℃ were the most favorable to reaction, and there was a linear relationship between fiber weight gain and amine concentration. In DMF medium, the amination reaction reached saturation within 1 h, and the increase of reaction liquid ratio was not conducive to the amination reaction. The higher epoxy group content of CPGMA, the better amination reaction. At 600 ℃, the residual amount of CPGMA(grafting rate was 198%) was 5.1%, while the residual amount of amine-modified CPGMA-EDA was 16.8%, and the thermal stability of the fiber increased. The disappearance of the tertiary carbon peak on the 5′ epoxide group and the reduction in the intensity of the methylene carbon peaks on the 2′-quaternary carbon and 6′ epoxide groups in the solid-state ¹³C CP/MAS NMR spectrum confirmed the success of amination reaction.