Abstract: 5 endo-isocamphanyl-formaldehyole thiosemicarbazide compounds(3a-3e) were synthesized by condensation reactions of camphene derivatives endo-isocamphanyl-formaldehyole with thiosemicarbazide derivatives. Their structures were characterized by IR, MS, ¹H NMR and ¹³C NMR. The mycelial growth rate method was used to study the inhibition effects of the related compounds on the growth of 8 plant pathogenic fungi including Rhizoctonia solani. The results showed that, among 5 compounds, the inhibition rate of endo-isocamphanyl-formaldehyole thiosemicarbazide(3a) was the highest against 8 plant pathogenic fungi. At the mass concentration of 50 mg/L, the inhibition rates of 3a against Colletotrichum gloeosporioides and Colletotrichum acutatum were 91.9% and 97.2%, respectively. The inhibition rates of 3a against Colletotrichum fructicola and Coriolus versicolor were both 100%. The inhibition rates of 3a against Rhizoctonia solani, Sphaeropsis sapinea and Fusariumoxyporum f. sp. niveum were 80.7%, 79.8% and 79.5%, respectively, which were better than that of the positive control sample of Chlorothalonil.