Abstract: Fatty acid methyl esters were produced by continuous transesterification using cottonseed oil and methanol as raw materials in the presence of catalyst and cosolvent in a static mixing tubular reactor. The reaction was carried out under the condition of KOH as catalyst(0.6 %), molar ratio of methanol to cottonseed oil 28∶1, volume ratio of oil to cosolvent of butanone 1∶1.5. The kinetics of continuous transesterification reaction were studied under reaction temperature of 45 ℃, 50 ℃, 55 ℃, 60 ℃ and 65 ℃ respectively. The results showed that the reaction can be finished in 15 minutes and the conversion of rapeseed oil was 98.7 %. The kinetic model from the experiment data was a pseudo-first-order reaction and activation energy of continuous transesterification was 11.9 kJ/mol.