沉香叶抗肿瘤活性化学成分研究

Antitumor Constituents from the Leaves of Aquilaria sinensis(Lour.)Gilg

摘要: 在抗肿瘤活性部位筛选的基础上,利用多种柱色谱方法对沉香属白木香叶中的化学成分进行了分离,通过理化常数和波谱分析鉴定其中所分得化合物的结构.从该植物中共分得10个化合物,结构分别鉴定为:洋芹素-7,4'-二甲醚(1)、木犀草素-7,3',4'-三甲醚(2)、木犀草素-7,4'-二甲醚(3)、芫花素(4)、木犀草素(5)、羟基芫花素(6)、2-O-α-L-鼠李糖-4,6,4'-三羟基二苯甲酮(7)、对羟基苯甲酸(8)、β-胡萝卜苷(9)、7α-羟基-β-谷甾醇(10).化合物7为新化合物,化合物1～6及8、10为首次从该植物中分到.

Abstract: Based on screening of antitumor activity, antitumor constituents in the crude extract from the leaves of Aquilaria sinensis(Lour.) Gilg, were isolated and purified by various chromatographic methods and were identified on the basis of spectral analysis and physico-chemical characters. Ten compounds were identified as 5-hydroxy-7,4'-dimethoxyflavone(1), luteolin-7,3',4'-trimethyl (2), luteolin-7,4'-dimethyl(3), genkwanin(4), luteolin(5), 3'-hydroxygenkwanin(6), 2-O-α-L-rhamnopy-ranosyl-4,6,4'-trihydroxybenzo-phenone(7), 4-hydroxybenzoic acid(8), β-daucosterol(9), 7α-hydroxysitosterol(10), respectively. The novel compound 7 was found for the first time. Compounds 1-6 and 8, 10 were isolated from this plant for the first time.