Abstract: The advances of research on metal complexes of effective components in natural medicines are reviewed. Current study shows that the objectives of study mainly are flavonoids, quinones, alkaloids and coumarins, in terms of pharmacologies of antitumor, antivirus and antimicrobial, as well as optical and magnetic properties, which will provide valuable conclusions on the multiple structures and properties of natural metal complexes with natural medicines,especially for the application development of new anti-tumour medicines.