Abstract: Urushiol resin catalyst doped chemically with molybdovanadophosphoric acid(UR-HPA) was prepared by polymerization method. The prepared resin was characterized by FT-IR and thermogravimetry(TG-D-TG). The results showed that chemical bond was formed between molybdovanadophosphoric acid and urushiol resin. The catalytic activity of the resin was investigated by synthesis of ketals. In the system of cyclohexanone-ethlene glycol ketal(CHGK) catalyzed by UR-HPA, CHGK yield is 88.4%. The catalyst can be reused for fifteen times, keeping CHGK yield at 85.2%.