Abstract: The regression model for factors affecting iodine adsorption of the prepared activated carbon was established and optimized by using Central Composite Design's central combination design and response surface method. The test of single factor showed the activated carbon with good adsorption properties prepared by mechanochemical process. The pore volume and pore size distribution of the prepared activated carbon under the optimum condition were derived from adsorption isotherms(N2 at 77 K). The results showed that the optimum technology condition include ZnCl2/wood flour ratio 3.00, milling time 10min, activation temperature 584 ℃, activation time 2.5 h.