Abstract: Tobacco stem and tobacco dust were used to prepare tobacco paper-base in this study. The effect of pressure in press section on the properties of tobacco paper-base was studied. The results indicated that tensile index gradually increased from 17.27N·m/g to 23.69N·m/g; tear index decreased from 2.00mN·m2/g to 1.69mN·m2/g, bulk decreased from 2.43cm3/g to 1.80cm3/g and density increased from 0.41g/cm3 to 0.56g/cm3 when the pressure increased from 0MPa to 0.4MPa. Meanwhile, the air permeability decreased from 1.20μm/(Pa·s) to 0.04μm/(Pa·s), and filling value gradually declined from 7.23cm3/g to 6.08cm3/g. Similar trends of max wettability value tW,max and t95 eigenvalue were observed with the increase of pressure. The lowest tW,max 0.097s and t95(t95 with characterizes the time point, paper is permeated by liquid and signal intensity of 95% after the maximum)0.442s were obtained as the pressure was 0MPa, and the tobacco paper-base showed better liquid permeability and surface structure. The SEM results revealed that the lower pressure (<0.2MPa) was beneficial for the improvement of the tobacco paper-base porosity, which was positive to enhance the filling value and air permeability, as well as the liquid permeability of tobacco paper-base.