Abstract: Central composite design and T-type correlation degree analysis was used for optimizing the extraction technique of yohimbinehydrochloride from African yohimbine bark. Based on single-factor experiment, three independent variables, namely:fraction ratio of ethanol, extracting time and solvent-solid ratio, were selected as affecting factors during extraction. The experiments were arranged according to central composite design and T-type correlation degree analysis.The results showed that the main factors affecting the yield of yohimbinehydrochloride were in sequence as follows:ethanol volume fraction＞extracting time＞solvent-solid ratio. The optimum technological conditions were as follows:ethanol volume fraction 90%(pH value 9), 3 times of reluxing extraction for 2.5, 2.0 and 1.5h, at solvent-solid ratio 10:1, 8:1, 6:1(mL:g) respectively. The yield of yohimbinehydrochloride was 8.76% and the content of yohimbinehydrochloride was 8.45%.