Abstract: A strain of Candida utilis which has high ability against the inhibitors in Ginkgo biloba L.leaves was screened. The effects of culture conditions on the C.utilis multiplication using G.biloba leaves as solid fermentation substrate and the changes of main nutritional ingredients and functional ingredients of the fermented products were also studied. The optimum culture conditions were: substrate thickness 2-4 cm in shallow tray fermentors; initial moisture content 60%; initial pH value 4.5-5.0; incubation temperature 28-30℃. The analysis of the fermented products showed that the content of flavone was reduced slightly. However, the number of yeast cells amounted to 4.0×109 per gram; and the contents of crude protein, total amino acids, necessary amino acids were increased 70.2%,40.77% and 14.73%, respectively.