The Optimization of Synthesis Process of Nopinone

Nopinone is an important forest derivative derived from the oxidation reaction of β-pinene, which is of great significance for further deep processing and utilization of naloxone.In this paper, the optimization for the synthesis process of nopinone from β-pinene was studied.The effects of reaction time, reaction temperature, type and amount of catalyst, n(potassium permanganate):n(β-pinene), type of oxidant, solvent type on reaction conversion and selectivity were discussed.The results showed that when the reaction time was 3 h, the reaction temperature was 21-24℃, the catalyst was cetyltrimethylammonium bromide (CTAB), the amount of catalyst was 0.20 g, the molar ratio of potassium permanganate to β-pinene was 3.2:1, using potassium permanganate as oxidant, acetone as solvent, the conversion rate of the synthesis reaction of nopinone is 99.5%, and the selectivity is 92.2%.