Abstract: The decoloring effect of 12 macroporous resins on crude polysaccharide extracted from white wax scale, Ericeruspela pela (Chavannes), was studied. The cellular antioxidant activity of crude and decolorant polysaccharide on proliferation effect of SH-SY5Y cells induced by hydrogen peroxide were evaluated. The resin NKA-9 was selected for kinetic study based on the results of adsorption properties comparing of macroporous adsorption resins and the static adsorption test. The dynamic adsorption and desorption experiments were conducted to establish the optimum parameters of NKA-9 as: one volume solution of crude polysaccharide was loaded in column at the flow rate 1 bed volume per hour under the condition of 30 ℃ and pH 8.0. The decolorant polysaccharide was collected by washing adsorbate-laden column using five bed volume of deionized water. The decoloration rate was 71.4%, the yield of polysaccharide was 60%, the deproteinization rate was 51.9%. The results of cellular antioxidant activity assay showed that the cell livability could be increased only at the concentration of 1 000 μg·mL-1 crude polysaccharide. But the decolorant polysaccharide at the concentrations of 10 1 000 μg·mL-1 could reduce the cell death rate of SH-SY5Y. Among them, the decolorant polysaccharide at the concentrations of 1 000μg·mL-1 could reduce the cell death rate notably. The cellular antioxidant activity of decolorant polysaccharide was enhanced after decoloring by NKA-9.