Abstract: Taking different aged persimmon varieties of ‘Gongchengshuishi’ (PCA cultivar), ‘Youhou’ and 'Jiro’ (PCNA cultivar) from Guangxi Zhuang Autonomous Region, Shanxi Province, Shaanxi Province and Yunnan Province as material, the occurrence time, disease symptoms, fruit drop time of persimmon fruit top rot disease, and the relationship between the disease and orchard site, tree age and other factors were investigated. The results showed that the disease occurred in veraison stage. The originating site of the disease of ‘Gongchengshuishi’ and ‘Yoho’ fruits was on the top of a little skin peel or pulp, then developed from outside to inside, while in ‘Jiro’ it started from flesh, developed from inside to outside. The speed of turning soft of infected fruits of ‘Gongchengshuishi’ and ‘Jiro’ were faster than those of ‘Youhou’. The sick fruits of ‘Gongchengshuishi’, ‘Jiro’ and ‘Youhou’ dropped respectively in 15, 20, 35 days after the appearance of the disease. The disease was more serious in weak trees. For ‘Gongchengshuishi’, the disease of orchards in flat area was more serious than in orchards in mountains. A strong negative relation was found between the disease and fruits amount of tree of ‘Youhou’ and ‘Jiro’, the correlation coefficients were: -0.872 and -0.895. The infected fruits of ‘Youhou’ and ‘Jiro’ were bigger than the healthy ones. For ‘Youhou’ and ‘Jiro’, the disease was more serious in upper and external canopy than lower and internal parts.