Abstract: Ten kinds of herbicide with different concentrations were sprayed on the stems and leaves of weeds in a one-year-old Amygdalus pcdunculata nursery. The results showed that the Chenopodiaceae and Poaceae weeds dominated in the nursery, and all the treatments had effect in controlling Chenopodiaceae weeds, while the treatment with the formula of 14% benazolin, 10.8% haloxyfop, 12.5% sethoxydim, 48% basagran, 10.8% haloxyfop+48% basagran, 12.5% sethoxydim+48% bentazone and 50% isoproturon had better effect in controlling Poaceae weeds. The herbicide-controlling spectrum of 50% isoproturon was the widest, and the 48% bentazone and 12.5% sethoxydim+48% bentazone treatment had the highest efficiency in weeds prevention, but both of them made serious damage on A. pcdunculata seedlings. The prevention efficiencies of 10.8% haloxyfop and 12.5% sethoxydim were 68% and 56% under high concentration treatment, and the A. pcdunculata did not represent injury symptoms, so they are suitable for weed prevention in the nursery of A. pcdunculata.