Abstract: In view of the problem that CMJD-1500 type plastic film residue collecting and balling machine was promoted in the Yellow River delta region, due to improper adjustment of operating parameters of pickup and packaging device, the residual film pick-up rate and the package molding rate were relatively low. Based on the experimental design principle of six factors and three levels Box-Behnken, the mathematical model between the key parameters, the residual film pick-up rate and the package molding rate was established, and the optimal combination of operating parameters of the prototype was determined,（The forward speed of the prototype is 4 km/h, the speed of the cleaning roller is 85 r/min, the speed of the eccentric pickup roller is 65 r/min, the speed of the large decorating roller is 390 r/min, the pressure holding time of the film envelope is 6 s, and the pressure of the pressing envelope is 7 MPa） and the relationship between the optimal operating parameters was analyzed. Field validation tests showed that the average pick-up rate of residual film of the machine was 94.67%, and the average package molding rate was 95.88%, and the test results met the requirements of relevant national standards. The results can be used as reference for the research and development of residual film picking and packaging equipment in the Yellow River delta.