Abstract: In this paper, the automatic path planning of spray plant protection machine is taken as the research object. Binocular vision camera is used to detect obstacles in the working environment area, and three-dimensional reconstruction technology is used to build the space position coordinates of obstacles. The obstacle avoidance path of spray plant protection machine is planned according to the location information of obstacles detected. Ensure the real-time obstacle avoidance of the spray plant protection machine. The experimental results show that the spray plant protection machine can advance according to the pre established working path. When encountering obstacles, it can detect obstacles in time and avoid obstacles according to the planning path, so as to ensure the effective implementation of spray operation.