Abstract: In order to address the problem of fertilizer blockage and leakage, the parameters of compound fertilizer were calibrated by funnel to improve the operation quality and efficiency. Firstly, the angle of repose was obtained and the static friction coefficient between particles and particle-steel static friction coefficient were determined by physical test. Subsequently, Hertz-Mindlin no slip was selected as the contact model, and the accumulation angle was used as the response value. The Plackett-Burman test was designed by Design-Expert software to select the parameters with the most significant effect on the accumulation angle. Next, seek out the optimal range of significant parameters through the steepest climbing test design. Furthermore, with the angle of repose as the response value, the Box-Behnken test was used to obtain the quadratic regression model of the angle of repose and the significant factors, and further to optimize, the optimal group solution was obtained: the collision recovery coefficient of compound fertilizer particles is 0.36, the coefficient of rolling friction between particles is 0.19, and the coefficient of rolling friction between particles and steel was 0.16. Finally, taking these results as test parameters to simulate, the errors between simulation and physical test is 1.76%. To sum up, the parameters calibration of compound fertilizer showed that the shape of the simulated accumulation angle was similar to the actual results, which could provide a reference for mechanical fertilizer production and agricultural fertilization.