Abstract: It firstly analyzes the principle of 5G wireless network positioning, and puts forward single base station positioning technology and weighted centroid 5G positioning technology, then designs the hardware design of the picking robot positioning system, and finally realizes the picking robot positioning system based on big data and wireless network. The test results showed that the system has good positioning accuracy, its positioning accuracy is better than that of single base station positioning method, and its positioning curve has very high fitting degree with Beidou positioning equipment curve, and its stability is also good.