Abstract: Through the teaching reform of mechanical design courses, a multi-level practical innovation teaching system integrating teamwork, learning, research, training and competition, online and offline, in-class and extra-curricular linkage, has been constructed that integrates innovative teaching, teamwork, scientific research, practical training and scientific and technological innovation competitions, with teamwork as the core. It has formed a student-centered teaching practice and collaborative atmosphere, which has taken a solid step for the cultivation of professional high-quality innovative talents. It aims to narrow the gap between the current talent goals of college graduates and the needs of enterprises, and solve the problems of poor practical operation, poor hands-on ability, weak teamwork and innovation awareness among graduates.