Abstract: This paper discusses the research on the design and application of case method in CNC machine tool teaching. Firstly, the concept and importance of case method in CNC machine tool teaching were introduced. Secondly, the principles and steps of case method design are analyzed, and some methods of case method design are proposed. Then, the application examples of case method in CNC machine tool teaching, and the role of case method in improving students’ practical ability and solving practical problems was analyzed. Finally, the role of case method in the teaching of CNC machine tools is summarized, and some suggestions for improving the case teaching are put forward.