Abstract: In order to screen effective fungicides and application methods for prevention and control of wheat Fusarium crown rot（FCR）, three test sites in Qihe County of Dezhou City, Mudan District of Heze City, and Huimin County of Binzhou City in Shandong Province were selected for field experiment．Experiment evaluated comprehensive prevention and control efficacy and yield of different seed coating treatments combined with rhizome spraying during tillering stage and before regreening and jointing stage on wheat FCR．Results showed that three seed treatments had no significant inhibitory effect on wheat emergence and seedling growth．Seeds treated with ipconazolein metalaxyl·ipconazole 4.23% ME+clothianidin 30% FS combined with trifloxystrobin · tebuconazole 30% SC sprayed on stem base at tillering stage before winter, and propiconazole · azoxystrobin 18.7% SC sprayed before regreening and jointing stage, had the best prevention and control efficacy on wheat crown rot．Prevention and control efficacy for three test sites at regreening stage reached over 75%, and over 82% at filling stage reached．It had a good effect on increasing wheat production, with an increase of 18.57%～26.18%．Therefore, this fungicide combination could be used in production to achieve purpose of controlling disease and ensuring production and could provide a reference for prevention and control of wheat FCR．