Abstract: The cooperation of politics, school, enterprise and practice is an important means of integration of production and teaching and training high-quality technical talents in higher vocational colleges. This paper analyzes and studies the existing problems of integration of industry and education in higher vocational colleges, finds out the crux of the matter, and innovates the long-term operating mechanism, with a view to providing reference materials for the cooperation of government schools and enterprises in educating people, promoting the deep integration of schools, enterprises and teaching, and ensuring the healthy and sustainable development of the cooperation education system of government, schools, enterprises and enterprises.