Abstract: Using seed-used pumpkin and Gala apple as the main raw materials, the compound fruit wine is obtained by the processing of seed-used pumpkin and apple pasting, enzyme hydrolysis and alcoholic fementation, and clarification. The best combination of processes obtained by orthogonal testing is: seed-used pumpkin and apple is 2:1, yeast amplification solution inoculation is 7%,initial glycosacity content 19%, initial pH is 4.0. The wine produced with the optimum conditiongs is brown, mellow and soft, slightly fragrance with seed-used pumpkin and apple. It is a new type of fruit wine with rich nutrition, unique flavor and broad development prospects.