Abstract: Antibiotics are the main category of drugs to suppress infectious diseases, and their application range is wide, especially for those poultry just infected or suffering from acute infectious diseases, have relatively good therapeutic effect, but for some chronic infectious diseases or until the disease deteriorates to the late stage of poultry, the therapeutic effect is not particularly outstanding.There is usually no effect on the prevention and control of livestock diseases caused by the virus, such as Newcastle disease. The effect depends on the type of microorganism. Reasonable use of antibiotics can enhance the effect of prevention and control, abuse of antibiotics not only cannot achieve the purpose of prevention and control of disease, on the contrary, will cause adverse consequences. Therefore, must pay attention to the relevant situation when taking medication.