Abstract: In recent years, the wheat planting area of Huoqiu County is expanding day by day, so it is urgent to apply the high-yield cultivation technology of wheat and implement the comprehensive prevention and control measures of diseases and pests. Through introducing the key points of wheat high-yield cultivation technology in Huoqiu County, the countermeasures and suggestions for the comprehensive control of wheat pests and diseases were discussed, in order to provide references for the improvement of wheat yield and quality.