Abstract: As an important place of scientific research, laboratory plays a very important role in the development of science and technology. Agricultural scientific research laboratory is an important platform for agricultural scientific research. It is urgent to solve the loopholes in the safety management of the laboratory. A safe and effective management system can not only improve the efficiency of scientific research, but also effectively prevent the occurrence of various hidden dangers. This paper analyzes some safety problems existing in the laboratory of agricultural research institute, and puts forward some suggestions on the safety management of the laboratory.