Abstract: The results showed that the effective panicle per unit area, grain number per panicle and grain yield of wheat treated with inorganic nitrogen alone were better than those treated with organic nitrogen alone and combined application of organic nitrogen and inorganic nitrogen. On the premise of comprehensive consideration of crop yield, economic benefits and environmental benefits,combined with this experimental study, the application of organic fertilizer instead of 20% chemical fertilizer can reduce the decrease of wheat yield to the greatest extent, increase nitrogen use efficiency and reduce environmental pollution.