Abstract: In view of the practical teaching of the compulsory course Maintenance of Engine Electronic Control System for the major of automobile manufacturing and testing technology in higher vocational colleges, the characteristics of students’ learning situation are investigated, and the actual needs of enterprises are connected. The teaching content of fault maintenance of engine electronic control system is reconstructed based on the actual working process of automobile maintenance workers. The course focuses on training students to master the skills of automobile engine fault diagnosis and exclusion, improving students’ professional quality and employment skills, and laying a solid foundation for students to engage in automobile repair work. In the course practice, teaching strategies are constantly optimized, teaching methods are improved, and evaluation methods are innovated. The automobile repair corporate culture is integrated into the course teaching, and the objectives of the curriculum politics are implemented. The teaching reform practice improves students’ learning efficiency and promotes students’ comprehensive development by the analysis of learning effect.