Abstract: With the continuous maturity of greenhouse technology, greenhouse cultivation has become the main mode of Lycopersivonesculentum cultivation, but under the influence of special cultivation management and environmental conditions in the shed, Lycopersivonesculentum diseases are increasing, especially late blight, leaf mold, gray mold, bacterial wilt, wilt, etc., which seriously affect the quality and yield of Lycopersivonesculentum. Based on this, the prevention and control technology of main diseases in greenhouse Lycopersivonesculentum cultivation was discussed from three aspects: symptoms, causes and green prevention and control, in order to provide reference for other Lycopersivonesculentum cultivation farmers.