Abstract: In order to actively explore new ways to control wheat diseases and insect pests and increase yield, the combination of brassinolide and pyraclostrobin was applied at jointing stage, booting stage and filling stage of wheat. The results showed that the combination of brassinolide and pyrazole ester could significantly promote the number of grains per spike and 1000 grain quality of wheat,and could significantly increase the yield of wheat, with the yield increasing rate of 15.02%.