Abstract: In order to explore the synergistic effect and precise application technology of different pesticides in the control of major wheat diseases and pests, the method of field random block treatment was used to spray 22% high-efficiency cypermethrin · thiamethoxam microcapsule suspension + 18.7% propiconazole · azoxystrobin EC + amino acid water-soluble fertilizer once at the turning green stage, jointing stage and filling stage of wheat, verify its control effect on main diseases and pests of wheat and its impact on yield formation. The results showed that the test chemicals had good control effects on wheat aphids, red spiders, powdery mildew and other major wheat diseases and pests, and the control effects were up to 95.22%, 93.74% and 90.72%; Under the experimental dose, the medicament had no adverse effect on the growth and development of wheat, and could effectively increase the number of grains per panicle and 1 000 grain quality, promote the increase of wheat yield, and the yield increase rate was up to 20.62%.