Abstract: Meloidogyne spp are fast in propagation and difficult to control, which can invade the roots of crops, affect the growth of plants,and lead to the decline of crop yield and quality. In this paper, the current research on the prevention and control of Meloidogyne spp with microbial agents was analyzed, and it was pointed out that the prevention and control of Meloidogyne spp with microbial agents was safe,efficient and pollution-free.