Abstract: In order to explore the control effect and safety of different fungicides on apple rust disease, apple trees affected by leaf rust disease in Baiyin area of Gansu Province were taken as the research objects, and the control effect of different treatment agents on apple leaf rust disease was investigated respectively during the prevention test before the outbreak and the treatment test after the infection of bacteria. The differences of transverse diameter, longitudinal diameter and single fruit quality of apple fruit after different application of different insecticides were compared. The results showed that in the test of different treatment agents applied before the onset of disease, the control effect of enazolol cream was significantly higher than that of other agents. In the test of different treatment agents applied after the infection of bacteria, the best control effect of triazolone cream was significantly higher than that of other agents. Compared with the control group, the effect of triazolone cream on fruit quality was relatively serious, and the effect of pyrazolacetin suspension on fruit quality was minimal.