Abstract: The application of mechatronics technology in the design and manufacturing process of small three-row wheeled maize harvester can bring the advantages of each sub-technology of this technology into full play, change the problems prone to occur in the design and manufacturing of traditional agricultural machinery, improve mechanical performance, and ensure the smooth progress of agricultural production. Promote the upgrading of agriculture in the direction of precision, automation and intelligence, and realize the development of agricultural mechanization. Based on the analysis of the value of mechatronics in the design and manufacture of agricultural machinery, taking the design and manufacture of small three-row wheeled maize harvester as an example, the specific application of mechatronics is explored, which provided useful reference for the research and practice in the field of agricultural machinery design and manufacture.