Abstract: In order to promote the resource utilization of Chinese medicinal materials waste,the physicochemical properties of different kinds of Chinese medicinal materials waste matrix were studied with vermiculite as the control （CK）,and the effects of vermiculite mixed with 2∶1 （volume ratio） on the agronomic properties of potato virus-free seedlings and the yield of potato original seed were studied.The experimental results showed that the physical and chemical properties of the compound matrix of Chinese medicinal materials waste after decomposition and vermiculite were within the range of normal plant growth,and both met the conditions for the production of potato original seed.The most suitable substrates were T₂and T₁.Compared with CK,the number of leaves and stem diameter increased by 13%,stem diameter increased by 6.2%,and plant height increased by 10%.Although the yield was lower than that of CK,the qualified potato blocks were basically the same as that of CK,and no disease occurred.Compared with CK,the number of leaves increased by 6.5%,stem diameter increased by 2.2%,and plant height increased by 21%.The yield and qualified potato were slightly lower than CK,but no disease occurred.