Abstract: In order to study and discuss the application effect of Wanjiafeng non-topping agent on machine-picked cotton, through the investigation and analysis of the agronomic characteristics, the proportion of three peaches and the yield structure of machinepicked cotton after spraying, the comprehensive analysis shows that the lint per mu of non-topping agent spraying treatment is increased by 1.2 kg/0.067 hm2and the yield increase rate is 0.65% compared with the control treatment, and the economic benefit results show that the net income per mu of non-topping agent spraying treatment is increased by 47.9 yuan/0.067 hm2 compared with the control treatment.